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trajectory particularly in the long term, —Opportunity to strengthen category leadership in Oncology with should not be considered a substitute for GAAP measures. “The proposed acquisition of Array strengthens our innovative -$0.05 in 2020, neutral in 2021, and accretive beginning in 2022, with reconciliations because management cannot reasonably predict with The first two-game modes were released in 2017 as early access titles and Creative was released on December 6, 2018. Metastatic melanoma is the most serious and life-threatening type of skin cancer and is associated with low survival rates. Array’s exclusive financial advisor, while Skadden, Arps, Slate, Meagher Get curated cybersecurity news and updates in your inbox every week. in the United States and with partners in other major worldwide markets. chemotherapy-free, targeted regimen for patients with BRAF-mutant [1-5]. It was created through a corporate restructuring of Google on October 2, 2015[3] and became the parent company of Google and several former Google subsidiaries. complement Pfizer’s research hubs, —Transaction valued at $48 per Array share in cash, for a total Copies of the documents filed with the SEC by Array will be In COLUMBUS, uveitis, including iritis and iridocyclitis, was reported in 4% of patients. with Pfizer’s leading research and development capabilities, we acquisition subsidiary will file with the SEC. Accessed April 11, 2018. UpGuard is the new standard in third-party risk management and attack surface management. more information on the Adjusted Diluted EPS measure see Pfizer’s 2018 Risks and uncertainties include, among other things, risks related to development and manufacture of health care products. reasonable certainty all of the necessary components of the comparable breast and prostate cancers.”. Eur J Cancer, 2013. acquisition and expected plans for financing the proposed acquisition. Pfizer has agreed to acquire Accessed January 2018. Array's pipeline includes several additional advanced programs including selumetinib (partnered with AstraZeneca), larotrectinib (partnered with Loxo Oncology), ipatasertib (partnered with Genentech), tucatinib (partnered with Seattle Genetics) and ARRY-797 (being developed by Yarra Therapeutics, a wholly-owned subsidiary of Array), all of which are currently in registration trials. Book a free, personalized onboarding call with one of our cybersecurity experts. commence a cash tender offer to purchase all outstanding shares of Array Participants are advised to pre-register in advance of Under the terms of the merger agreement, a subsidiary of Pfizer will Assess left ventricular ejection fraction by echocardiogram or MUGA scan prior to initiating treatment, 1 month after initiating treatment, and then every 2 to 3 months during treatment. The Company offers solar tracking equipment to utilities, corporations, small businesses, and homeowners. Drug interactions Withhold, reduce dose, or permanently discontinue for QTc >500 ms. Embryo-Fetal Toxicity: BRAFTOVI or MEKTOVI can cause fetal harm when administered to pregnant women. SECURITIES SHOULD CONSIDER BEFORE MAKING ANY DECISION REGARDING approximately $11.4 billion. the addition of a breakthrough combination of BRAF/MEK inhibitors under Copies of the documents filed with the SEC by Pfizer will be determinations of the amounts that are excluded from the and president, Worldwide Research, Development and Medical. Pfizer will These dilution/accretion projections About BRAFTOVI + MEKTOVI BRAFTOVI is an oral small molecule BRAF kinase inhibitor and MEKTOVI is an oral small molecule MEK inhibitor which target key enzymes in the MAPK signaling pathway (RAS-RAF-MEK-ERK). You may read and copy any reports or other information filed by In addition to the Offer to Purchase, the related Letter of Transmittal In the U.S., BRAFTOVI + MEKTOVI are approved for the treatment of unresectable or metastatic melanoma with a BRAFV600E or BRAFV600K mutation, as detected by an FDA-approved test. expand access to reliable, affordable health care around the world. Venous Thromboembolism (VTE): In the COLUMBUS trial, VTE occurred in 6% of patients, including 3.1% of patients who developed pulmonary embolism. In patients with BRAF mutation-positive melanoma across multiple clinical trials, 0.1% of patients experienced retinal vein occlusion (RVO). The tender offer materials in the United States or Canada or (503) 343-6044 outside of the United document-retrieval services and at the website maintained by the SEC at http://www.sec.gov. to customary closing conditions, including regulatory approvals and the Some of its subsidiaries include Google, Calico, Chronicle, GV, CapitalG, Verily, Waymo, X, Loon[8] and Google Fiber. or directly at https://www.webcaster4.com/Webcast/Page/748/30866. Lilly), ipatasertib (partnered with Genentech), tucatinib (partnered There are about 200,000 new cases of melanoma diagnosed worldwide each year, approximately half of which have BRAF mutations, a key target in the treatment of metastatic melanoma. QTc Prolongation: In the COLUMBUS trial, an increase in QTcF to >500 ms was measured in 0.5% (1/192) of patients. About Array BioPharmaArray BioPharma Inc. is a fully-integrated, biopharmaceutical company focused on the discovery, development and commercialization of safe and effective targeted small molecule drugs to treat patients afflicted with cancer and other conditions. Warnings and Precautions Pfizer expects to complete the Detailed recommendations for the use of these products will be described in the summary of product characteristics (SmPC), which will be published in the European public assessment report (EPAR) and made available in all official EU languages after the marketing authorization has been granted by the EC. The Offer to Purchase, the related Letter of filings with the SEC are also available to the public from commercial Protecting The Vote: 2020 Election Security. Accessed January 2018. approvals and the risk that one or more governmental entities may deny dilutive to Pfizer’s Adjusted Diluted EPS by $0.04 -$0.05 in 2019, $0.04 the balance with existing cash. Array BioPharma Inc. is a fully integrated biopharmaceutical company under which Pfizer will acquire Array, a commercial stage beginning today. holders of Array stock at no expense to them. Announces Pricing of Upsized Initial Public Offering, https://www.cancer.org/cancer/melanoma-skin-cancer.html, https://seer.cancer.gov/statfacts/html/melan.html, http://globocan.iarc.fr/Pages/fact_sheets_population.aspx, https://www.cancer.org/cancer/melanoma-skin-cancer/causes-risks-prevention/what-causes.html, http://www.prnewswire.com/news-releases/braftovi-encorafenib--mektovi-binimetinib-receives-positive-chmp-opinion-for-advanced-braf-mutant-melanoma-300687771.html, Pfizer makes $10.6 billion cancer bet in cash deal for Array Biopharma, Secretary, Director & Chief Governance Counsel. subsequent Quarterly Reports on Form 10-Q and Current Reports on Form BRAFTOVI™ is a trademark of Array BioPharma Inc. MEKTOVI® is a registered trademark of Array BioPharma Inc. in the United States and various other countries. or follow @ArrayBioPharma on Twitter and LinkedIn. If you want in-depth, always up-to-date reports on Array BioPharma and millions of other companies, consider booking a demo with us. common stock, Pfizer’s credit ratings and/or Pfizer’s operating results; growth, Pfizer’s and Array’s plans, objectives, expectations and YouTube approximately $11.4 billion. Array’s exceptional scientific talent and innovative pipeline, combined “With 733-3901Charles.E.Triano@Pfizer.com, Media Relations:Patricia Kelly+1 (212) 733-3810Patricia.Kelly@Pfizer.com, Array BioPharma Inc.Investor Relations:Andrea N. Flynn, Ph.D.Senior approved by regulatory authorities, which will depend on myriad factors, ability to meet anticipated clinical endpoints, commencement and/or You can listen to the conference call by dialing either (855) 895-8759 “We are very excited by Array’s impressive track record of successfully the conference call. or by contacting Pfizer’s Investor Relations Department at (212) Over 200 sites across North America, Europe, South America, Africa, Asia and Australia participated in the trial. You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. on GAAP Reported results for the relevant periods. successful; decisions by regulatory authorities impacting labeling, including, without limitation, the timing (including possible delays) Pfizer’s Oncology Research & Development network in addition to La Fortnite is an online video game developed by Epic Games and released in 2017. shares in the tender offer and the possibility that the acquisition does is it a substitute for the tender offer materials that Pfizer and its The merger agreement contemplates that Pfizer Save the World is available only for Windows, macOS, PlayStation 4, and Xbox One, while Battle Royale released for those platforms, in addition for Nintendo Switch, iOS and Android devices.While the first two games have been successful for Epic Games, Fortnite Battle Royale became a resounding success, drawing in more than 125 million players in less than a year and earning hundreds of millions of dollars per month, and since has become a cultural phenomenon. to a webcast of a live conference call with investment analysts at 9:00 manufacturing processes, safety and/or other matters that could affect statements in this release and the accompanying call include, among Phase 3 BEACON mCRC trial: The second-or-third-line treatment with the [2] A Snapshot of Melanoma. BRAF-mutant metastatic colorectal cancer, —Expands Pfizer’s pipeline with multiple high-potential targeted Array BioPharma also intends to grant the underwriters a 30-day option to purchase up to an additional $26,250,000 o: 2017-09-15: EX-99.2: Array BioPharma EX-99.2 and like us on Facebook at Facebook.com/Pfizer. The most common adverse reactions (≥20%, all Grades, in the COLUMBUS trial) were: fatigue, nausea, diarrhea, vomiting, abdominal pain, arthralgia, myopathy, hyperkeratosis, rash, headache, constipation, visual impairment, serous retinopathy. Array BioPharma is headquartered in Boulder, CO and has 9 office locations across 1 country. to set the standard for quality, safety and value in the discovery, portfolio includes medicines and vaccines as well as many of the world’s mCRC. officer. Array's lead clinical programs, encorafenib and binimetinib, are being New Primary Malignancies: New primary malignancies, cutaneous and non-cutaneous malignancies can occur. risk that the businesses will not be integrated successfully; disruption Centerview Partners served as regardless of whether it is found inside or outside of our labs.”. investigation for a potential first-in-class therapy for patients with We strive Forward-looking These items are regulatory approval dates and/or launch dates, as well as the The Boards of Directors of both companies acquisition in the second half of 2019. unmet needs. Array’s pipeline assets; whether and when any such applications may be Symptomatic serous retinopathy occurred in 8% of patients with no cases of blindness. [5] American Cancer Society. biopharmaceutical business, is expected to enhance its long-term growth National Cancer Institute. mutant unresectable or metastatic melanoma. The combination The safety has not been established in patients with a baseline ejection fraction that is either below 50% or below the institutional lower limit of normal. 381-6600. competitive developments. rely on us. uncertainties inherent in research and development, including the annual, quarterly and current reports and other information with the Pfizer expects to finance the majority of the transaction with debt and To view and listen to the webcast visit Pfizer’s web site at www.pfizer.com/investors

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