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theophylline solubility

2005 May;22(5):784-8. doi: 10.1007/s11095-005-2595-6. theophylline has two pKa values: aromatic 'N' pKa= 1.0 and aromatic 'NH' pKa=9.0. This enabled for ranking of potential cocrystals formers according to their solubility enhancement potential. Solubility & Handling Chemical Data Related Areas Calculators Technical Guides ( 1) Reviews. Experimental determinations of diffusion coefficients in dilute aqueous solution using the method of hydrodynamic stability. 1991 May;8(5):643-8. doi: 10.1023/a:1015817109932. J Pharm Sci. A small amount of Theophylline is produced in liver by metabolizing Caffeine. Application: Theophylline is an inhibitor of cyclic phosphodiesterase. Increasing hydrophilicity of poorly water-soluble drugs is a major challenge in drug discovery and development. Southard MZ, Dias LJ, Himmelstein KJ, Stella VJ. Pharm Res. Applications. The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high . Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical acids and their sodium salts. Its most common use is in the treatment of airway obstruction from asthma or COPD. ; Tippet, P., Capillary gas chromatographic drug screen for use in forensic toxicology, J. Anal. II. It is also moderately soluble in ethanol (1.5 g/100 mL). 1. Adenosine receptor antagonist and cyclic phosphodiesterase inhibitor. Solid state chemistry of hydrate forming compounds Theophylline has also been used here as a model compound to study eo crystallisation with various saturated, dicarboxylic acids. Chromatogr., 565, 1991, 207-224. ass: Standard non-polar; Column diameter: 0.53 mm; Column length: 10 m; Column type: Capillary; Heat rate: 5 K/min; Start T: 130 C; End T: 230 C; CAS no: 58559; Active phase: DB-1; Carrier gas: He; Phase thickness: 2.65 um; Data type: Normal alkane RI; Authors: Anderson, W.H. 5.Not only wavelength can also give brief idea of mobile phase also. ; Ballantyne, D.J. Molecular Weight: 180.2. All chapters in this book are written by professionals in the areas of alkaloid chemistry, biology, pharmacy, and other interesting applications. Found inside – Page 128Soluble salts of theophylline with ethylenediamine are the dominating theophylline preparations world-wide for intravenous use. The active moiety of the theophylline salts is theophylline itself, the strongly basic fractions have no ... Syrup can be considered to be the newly developed dosage form and can be moved forward for the analytical development. Abstract: Theophylline is used to treat respiratory problems like COPD and asthma (bronchitis, emphysema). Theophylline (3-methyxanthine) has been used to treat airway diseases for over 70 years. 1,3-Dimethyl-3,9-dihydro-1H-purine-2,6-dione, Cn1c2c(c(=O)n(c1=O)C)nc[nH]2 Theophylline SAFETY DATA SHEET Supersedes Revision: 12/03/2017 according to Regulation (EC) No. The Second Method found in European Pharmacopeia 6.0 Potentiometric method where Titrant 0.1 M Perchloric acid is while Titrate 0.2 g Etofylline in 50 ml Acetic anhydride. Found inside – Page 336Theophylline is only sparingly soluble in water. The salts of theophylline, however, are more readily soluble and many theophylline salts were prepared to increase solubility and absorption. Aminophylline, for example, is the ethylene ... Found inside – Page 10-4THEOPHYLLINE or reis It is an alkaloid . ... It is slightly soluble in water but soluble in solution of alkali hydroxide . In order to increase solubility of theophylline , its ethylenediamine salt is prepared which is named as ... Product Name: Sodium theophylline (CAS NO.3485-82-3) Molecular Formula: C 7 H 8 N 4 NaO 2 Molecular Weight: 203.15379g/mol Mol File: 3485-82-3.mol Einecs: 222-472-9 Appearance: A white crystalline powder, no odor Boiling point: 271.1°Cat760mmHg Flash Point: 117.8°C Water Solubility: Soluble in water, insoluble in ethanol Adverse effects can occur within the range 10-20 mg/litre and both the frequency and severity increase at . The effect of dihydroxypropyl theophylline on the solubility and stability of menadione was investigated. Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory disease s such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. A comprehensive Literature review is prepared for Theophylline and Etophylline. Chromatogr., 374, 1986, 73-85. ass: Standard non-polar; Column diameter: 0.49 mm; Column length: 25 m; Column type: Capillary; Heat rate: 8 K/min; Start T: 100 C; End T: 275 C; End time: 15 min; Start time: 2 min; CAS no: 58559; Active phase: SE-30; Phase thickness: 1.14 um; Data type: Kovats RI; Authors: Schepers, P.; Wijsbeek, J.; Franke, J.P.; de Zeeuw, R.A., Applicability of capillary gas chromatography to substance identification in toxicology by means of retention indices, J. Forensic Sci., 27(1), 1982, 49-60. umn class: Standard non-polar; Column length: 2 m; Column type: Packed; CAS no: 58559; Active phase: OV-1; Carrier gas: N2; Substrate: Chromosorb G, AW-DMCS; Data type: Kovats RI; Authors: Berninger, H.; Grunnagel, R.; Mall, S.; Moller, M.R., Gas chromatographic identification of unknown substances from body fluids by menas of retention indices, Beitr. The dissolution kinetics of theophylline monohydrate and anhydrous theophylline were investigated with a rotating-disk apparatus in buffer solutions at 298 K under sink conditions. Notes. Found inside – Page 444... upon theophylline solubility and hence to test the robustness of the formulation with regard to this parameter. Starting from the overall centroid, corresponding to the maximal value of solubility, an experimental region was defined ... It has a role as a vasodilator agent, a bronchodilator agent, a muscle relaxant, an EC 3.1.4. Examples - The solubility of caffeine is increased by sodium benzoate. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. HPLC method was convincing having mobile phase as Acetonitrile and 50 mM Sodium Acetate Buffer having ratio of (15:85, v/v) where pH was adjusted to pH 6.0 with dilute Hydrochloric Acid, Column of Hi-Q-Sil C18 (250 mm × 4.6 mm, 5 μm) dimensions where selected and the flow rate was found to be 1 ml/min wavelength of 270 nm.

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